Major Depressive Disorder is considered a mood disorder which includes distressing symptoms such as sadness and emptiness, affecting sleep, eating and work functions. Those suffering from major depressive disorder often described themselves as feeling “blah,” and have lost interest and motivation in activities that use to bring pleasure or joy.

To be diagnosed with major depression, the symptoms must be present for at least 2 weeks.

According to the National Institute of Mental Health, major depressive disorder is the most common mental disorder with nearly 16 million adults suffering from depression with median onset of 32, although depression symptoms can manifest in adolescents. Depression is more likely in women than men, and according to the World Health Organization, the leading cause of disability among women internationally. (cite Selecting Effective Treatments.)

While a depressive episode can occur only once, most depressive episodes are reoccur throughout a person’s lifetime.

Types of Depressive Disorders

The two most common depressive disorders are:

Major Depressive Disorder – symptoms are consistent, occurring almost all day and nearly every day for two weeks.

Persistent Depressive Disorder – characterized by depressive episodes occurring nearly every day for at least two years.


Other additional types of depressive disorders include:

Premenstrual Dysphoric Disorder (PDD) – is a severe form of Premenstrual Syndrome (PMS) that happens during the menstruation cycle. PMD can cause extreme mood changes and severe physical symptoms that can affect work and others activities. ‘

Disruptive Mood Dysregulation Disorder (DMDD) – is a childhood mood disorder characterized by severe and recurrent temper tantrums, anger and irritability that is disproportionate to a situation or circumstance. The average onset of DMDD is around 10-years-old and requires a diagnosis by a licensed psychiatrist or mental health therapist to rule out other a differential diagnosis such as ADHD, anxiety or oppositional defiant disorder.


Causes of Major Depressive Disorder

While they are no definitive causes of depression, there are several factors that can trigger depressive disorders. Those include:

Genetics – The causes of depressive disorders aren’t fully understood, but studies have found that depression is common in people whose first-degree relatives – parents, siblings – also have the illness.

Brain structure – Recent studies have shown that those who suffer from depressive disorders appears to have changes in brain structure. While more research is needed, finding may help with determine the cause of the disorder.

Hormones – Changing hormones may play a role in depressive symptoms, particularly in women who undergo hormone changes before and after pregnancy, as well as during menopause.


These factors may increase your risk of developing a depressive disorder:

Trauma – Those who experienced a traumatic event, including sexual abuse, violence or the death of a loved one.

Genetics – Those with first-degree relatives who suffer from depressive disorders are at a great risk of having the illness.

Personality traits – Those who struggle with low self-worth and self-confidence are at a greater risk of symptoms.

Substance or alcohol abuse – Those who are abusing alcohol or drugs, as well as those are struggling with rehab or recovery.

LGBTQ – Those who have identified as LGBTQ or are struggling with their sexual identity and lack a support system are at greater risk for depression.


Signs and Symptoms

According to the Diagnostic and Statistical Manual of Mental Disorders (DSM), a reference manual used by health care professionals as the authoritative guide to the diagnosis of mental disorders, the signs and symptoms of major depressive disorder includes:

  • Depressed or low mood for most of the day, nearly every day for at least two weeks
  • Little to no interest in activities or tasks
  • Decrease in appetite and/or weight
  • Trouble sleeping or desire to sleep all the time
  • Lack of energy
  • Feelings of low self-worth
  • Lack of concentration or focus
  • Recurrent thoughts of suicide or death with plans or attempts


Please note that if you are experiencing manic episodes—drastic changes in one’s mood and energy states— then you may be suffering from Bipolar Disorder, formerly known a manic depression. In any case, our trained psychiatrists and therapists will help you find your diagnosis and proper treatment.


Children and Depression

Children and teens can be diagnosed with major depressive disorder, and exhibit the same symptoms as adults, however, additional symptoms include anger and irritability.

Disruptive Mood Dysregulation Disorder (DMDD) is also a childhood depressive disorder that is characterized by several temper tantrums, as well as extreme anger and irritability. These symptoms are persistent and occur nearly every day for 12 months or more.


Assessment for Major Depressive Disorder

A diagnosis of major depressive disorder or other depressive disorders requires an evaluation and diagnosis by a licensed clinician such as a psychiatrist or psychologist who specializes in depressive disorders. At Clarity Clinic, we specialize in depressive disorder assessments and treatment for children, teens, and adults aimed at understanding the severity, length and frequency of the symptoms, including ruling out a differential diagnosis, to determine the best treatment options.


Treatment for Major Depressive Disorder

Both medication and psychotherapy in conjunction have been shown to be effective in helping reduce symptoms of major depressive disorders. At Clarity Clinic our experienced clinicians guide clients towards the proper treatments, including pharmacological and non-pharmacological interventions.

Our psychiatrists ensure a proper diagnosis and take care in specialized medication management for clients treating depressive disorders through pharmacological treatment.


Medication Management

Medication management coupled with psychotherapy has proven to be an effective treatment in reducing symptoms of depressive disorders and improve overall functioning.
Medications to treat depression

At Clarity Clinic, we have highly trained staff who specialize in diagnosing and treating depressive disorders. To schedule an appointment, click on one of the specialists below to schedule an initial evaluation to and discuss assessment, diagnosis and treatment options.


Additional Resources

For more information on depressive disorders, below are several additional resources to help learn more: