If you’ve ever felt like you’ve tried everything for your depression and nothing seems to work, you’re not alone—and you’re not out of options! While more traditional depression treatments like antidepressants and talk therapy help many, those suffering from treatment resistant depression may need to explore other options in order to find relief.
That’s when alternative therapies such as Transcranial Magnetic Stimulation therapy (TMS) and ketamine nasal spray (esketamine) come into the picture. One uses non-invasive magnetic pulses to stimulate your brain. The other is a fast-acting nasal spray designed to bring rapid relief when you need it most.
Both innovative therapies are FDA approved for treatment-resistant depression, making waves in the mental health care community. Let’s take a deeper look and break down everything you need to know about TMS vs. Ketamine for depression—how they work, what to expect, and more.
Transcranial Magnetic Stimulation (TMS for depression) is a non-invasive, FDA-approved treatment for depression that uses magnetic pulses to stimulate areas of the brain involved in mood regulation. TMS is typically recommended for individuals who haven’t responded well to antidepressant medications.
Before diving into what ketamine nasal spray is, it’s helpful to understand what ketamine is. Originally developed as an anesthetic, ketamine has gained attention in mental health for its rapid-acting effects on depression—especially for individuals who haven’t found relief with traditional treatments. Head to our blog “Ketamine: A Potential Treatment for Depression and Other Mental Health Disorders” to learn more.
Ketamine nasal spray refers specifically to esketamine, a derivative of ketamine that’s been FDA-approved under the brand name Spravato® for treating treatment-resistant depression (TRD). Esketamine is administered as a nasal spray in a certified medical office under supervision and cannot be taken home.
Ketamine works differently from standard antidepressants by targeting glutamate receptors in the brain, leading to fast-acting relief from depressive symptoms—often within hours or days. Ketamine nasal spray (esketamine treatment) is always used in combination with an oral antidepressant and is typically recommended for those who have tried two or more antidepressants without success.
Because of its fast acting nature, it is typically suggested to help treat individuals who are suffering from severe depression with suicidal thoughts.
Here is a breakdown of some of the key differences between TMS for depression and Ketamine nasal spray for depression:
Type:
How it works:
Onset of Relief:
Treatment Schedule:
Side Effects:
Best For:
Both TMS therapy and ketamine therapy for depression can be effective, but the best treatment depends on your specific needs and medical history. It’s always best to speak with your psychiatrist or mental health care provider about your treatment plan.
TMS may be a better fit if you:
Ketamine may be ideal if you:
Disclaimer: The information on this page is for educational and informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with any questions regarding a medical condition or treatment. Never ignore or delay seeking professional help due to information found here.
Clarity Clinic offers the best TMS therapy in Chicago with TMS clinics in convenient locations (Loop and Arlington Heights). Additionally, our Chicago psychiatrists provide world class mental health care both in-person and virtually so you can access mental health support in a way that fits your lifestyle.
Whether you're exploring TMS therapy near you for treatment-resistant depression, seeking other forms of depression treatment, or simply seeking expert psychiatric care and medication management in Illinois, Clarity Clinic is here to help you find lasting relief. Take the first step toward feeling better—schedule your consultation today.
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Does ketamine therapy get you high?
Yes, ketamine therapy can cause a temporary dissociative or euphoric effect during treatment, but clinics use controlled doses to minimize abuse potential.
How long does ketamine work for depression?
Ketamine’s antidepressant effects typically last a few days to a few weeks. Maintenance treatments (every few weeks/months) may be needed for sustained relief.
How many ketamine treatments for depression?
This varies depending on the patient and what your physician believes to be best. Typically, you take 2 treatments per week (total of 8 sessions) for the first 4 weeks and then 1 treatment per week for the next 5-8 weeks.
Maintenance: After 8 weeks, frequency may reduce to every 2 weeks or monthly, depending on response.
Which is more effective, TMS or esketamine?
Both are effective, but esketamine (Spravato) often works faster (hours/days), while TMS provides gradual relief over weeks with longer-lasting effects for some.
What is the difference between transcranial magnetic stimulation and Spravato?
TMS: Non-invasive brain stimulation using magnetic pulses. Does not involve medication, instead it works by enhancing or inhibiting brain activity in targeted areas. Generally well-tolerated; most common side effects are scalp discomfort, headache, or lightheadedness. Gradual improvement over weeks to months
Spravato: Nasal spray containing esketamine (a ketamine derivative), taken with oral antidepressants under supervision. Fast acting results; great for patients who have suicidal thoughts. Can cause dissociation, dizziness, sedation, increased blood pressure, and potential for abuse (due to ketamine-like effects).
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