Trazodone Side Effects, Uses, & More

June 15th, 2020

When it comes to depression treatment, Trazodone is a medication that often comes up as an effective option. Originally developed as an antidepressant, Trazodone has also gained popularity for its off-label use in treating insomnia due to its sedative properties. Whether you're prescribed Trazodone for depression, sleep issues, or anxiety, understanding how this medication works, its uses, and potential side effects is crucial to making informed decisions about your treatment.

Keep reading to take a deep dive into Trazodone's side effects, uses, and more to help you get a clearer picture of what to expect and how it might fit into your health journey.

What is Trazodone?

Trazodone is a serotonin modulator medication used to treat depression. During the early 1980s, trazodone became commonly prescribed for patients who experienced symptoms of depression. Although trazodone is mainly used as an antidepressant, doctors may prescribe it to patients with other complications; such as schizophrenia or anxiety.

Trazodone is classified under a category of medicine known as serotonin modulators. Serotonin is a neurotransmitter, chemical in the brain, that works by sending signals between nerves. This chemical is used to regulate mood, appetite, sleep, memory, digestion, and sexual desire. Serotonin modulators target multiple serotonin receptors to slow down the reuptake of serotonin which leads to a higher concentration of serotonin to be used in the brain.

Trazodone Side Effects

Here is a list of Trazodone side effects, keep in mind some side effects are more severe than others:

Headaches
Nausea or vomiting
Loss or increase of appetite that may cause a change in weight
Dry mouth or weird taste
Dry eyes or blurred vision
Drowsiness, dizziness, tiredness
Sweating
Loss of balance
A possible loss of sexual interest or erectile dysfunction in men
Nightmares
Constipation
Fainting or vertigo

If side effects become severe, do not hesitate to contact your physician.

Toxic Trazodone Side Effects

Some of the more severe Trazodone side effects may be toxic; these may or may not include:

Increases maximum plasma concentrations (the fluidity of blood) which will cause it to be thicker.
Liver abnormalities may occur in patients who over use trazodone. The increased consumption will grow the levels of enzymes in the liver.

Trazodone Precautions

Given the nature and possible side effects of taking a drug like trazodone, it is important to understand its safety precautions.

Keep away from children
Consume a lot of water
Trazodone should not be consumed while taking other drugs; it is recommended to inform your doctor of all the drugs you are currently taking before beginning treatment with trazodone
People who consume trazodone may experience similar side effects, but every person may react differently
Not recommended to take on an empty stomach
If taking an extended release tablet, take it either 1 hour before or 2 hours after a meal
It is best to take before bed and only at this time may you take it on an empty stomach
Do not crush or chew
See if drinking grapefruit juice or eating grapefruits may increase side effects

Ensure you speak to your physician about possible side effects and precautions you can take while on the medication.

Trazodone for Sleep

Trazodone can be prescribed as a use for sleep related issues such as:

Insomnia collectively includes the difficulty falling asleep, staying asleep, and waking up early.
Prescribed for patients when their everyday life becomes affected due to their sleeping issues. Usually, a doctor will prescribe trazodone at a lower dosage if the targeted end use is to increase sleep. Please consult your doctor for your ideal Trazodone max dosage for sleep, as this can vary per person.
It is recommended to consume this antidepressant drug before bed.
Drowsiness is a side effect of taking Trazodone to help diminish depression. In terms of treating patients who suffer from insomnia, this Trazodone side effect may actually be found helpful.
Trazodone may replace the prescription known as Ambien, which is used to treat insomnia.

Trazodone for Depression

In some cases of depression, trazodone can be taken as a major depression disorder medication to help control and manage depression symptoms.

Trazodone’s main goal is to regulate the brain chemicals used to promote positivity, mood and social behavior.
Because of its low consumer costs, it is commonly known as the most economical efficient way to treat depression.

Trazodone Used in Treating Cocaine Withdrawal

The effects of trazodone can help to reverse the use of drug addiction, such as cocaine use.

There are times when the human body can develop a dependence on cocaine because it is a highly addictive drug
Cocaine withdrawal may cause a person to feel higher levels of anxiety, depression, and they may have a harder time sleeping
Trazodone can increase the chance of a person falling asleep and weaning themselves off of cocaine.

Trazodone Used in Treating Dementia

Some doctors may prescribe the use of trazodone when an individual is battling dementia.

Dementia is a mental disorder that causes people to lose their short-term memory or other thinking skills. This will reduce their abilities to perform everyday tasks
Trazodone is used in replacing antipsychotic drugs in treating dementia; this is because the side effects from antipsychotic drugs are more severe

An old man looking at his pill waiting to take it with water

Pregnant Mothers and Trazodone

Some expecting women may be ordered to take trazodone for specific mental health concerns.

It is highly recommended that you speak with your doctor before taking
There are tests that prove trazodone having no negative effects on the fetus

Trazodone for Dogs

Used not only to treat mental health in humans, trazodone is sometimes used to treat a variety of issues in dogs.

May be used to treat dogs who experience separation anxiety from their owners, behavioral issues, and trouble sleeping
Doctors may prescribe trazodone for daily consumption. Depending on the size of the dog and how serious their condition may be, the vet will prescribe different dosages
Trazodone is found in veterinary medicine used to treat animals, predominantly dogs, after they have surgery
This medicine regulates brain chemicals, specifically serotonin, and helps keeps animals comfortable post surgery
There are also side effects that dogs, other animals, may experience when taking trazodone
Vomiting or diarrhea
Restlessness or shaking
Tremors
Hyperthermia or hypothermia
Panting

A dog looking at an open pill bottle trazodone

Trazodone and Alcohol

Combining Trazodone and alcohol is generally not recommended. Both substances have sedative effects, and using them together can increase the risk of extreme drowsiness, dizziness, impaired coordination, and even respiratory depression. Drinking alcohol while on Trazodone can also reduce the effectiveness of the medication and potentially worsen depression or anxiety symptoms.

Trazodone and Lexapro

Combining two medications that affect serotonin levels such as Trazodone and Lexapro can increase the risk of serotonin syndrome, a rare but serious condition. Always follow your doctor’s guidance and report any unusual symptoms like confusion, rapid heart rate, or muscle stiffness.

Trazodone and Gabapentin

Both Trazodone and Gabapentin medications can cause sedation, so taking them together may enhance drowsiness, dizziness, and impair coordination. Close monitoring by your doctor is important to ensure the combination is safe and effective for your specific needs.

Trazodone and Xanax

Trazodone and Xanax (Alprazolam) are both sedative medications but belong to different classes—Trazodone is an antidepressant, while Xanax is a benzodiazepine. When taken together, they can significantly increase sedation, drowsiness, and dizziness, potentially impairing motor coordination and cognitive function. This combination should be used with caution and under close supervision by a healthcare provider to avoid excessive sedation and other risks, such as respiratory depression or dependence on Xanax. Always follow your doctor's instructions when using these medications together.

Clinical Psychiatrist in Chicago

Trazodone has been used to help treat symptoms of depression, anxiety, and panic attacks for almost 40 years. When appropriately taken, this drug can have significant positive effects in treating an individual for specific needs.

If you or someone you know is suffering from depression, anxiety, or other mental health disorders, Clarity Clinic can help. We offer the best psychiatrists in Chicago that can determine if medications like Trazodone are the right fit for you. Our mental health clinics offer online psychiatrists, medication management, psychiatric evaluations, TMS therapy, IOP/PHP programs, and more.

If you’ve noticed that depression medication does not work, and have been diagnosed with treatment resistant depression, our TMS therapy services could be a great option. Schedule an appointment today to speak to the best psychiatrist near you and improve your mental health.

Important Notice: The information provided on this page is for educational and informational purposes only. It is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay in seeking it because of something you have read here.

Find a Psychiatrist

Related Readings:

Using Gabapentin For Anxiety

Trazodone Commonly Asked Questions

What is Trazodone used for?

Trazodone is primarily used to treat depression. However, physicians have been known to use Trazodone to help treat other conditions such as anxiety and insomnia.

Is Trazodone a controlled substance?

No, Trazodone is not a controlled substance. While Trazodone is a prescription medication, it is not classified as a controlled substance by the U.S. Drug Enforcement Administration (DEA). This means it has a lower potential for abuse and dependence compared to medications that are controlled substances, such as benzodiazepines or opioids.

Why is Trazodone not helping me sleep?

If Trazodone is not helping you sleep, there could be an issue with your Trazodone dosage, the timing of administration, built tolerance over time, or Interactions with other medications or substances like caffeine and alcohol. Speak to your doctor to determine why Trazodone is not helping you sleep.

Does Trazodone cause weight gain?

Yes, Trazodone can potentially cause weight gain, although it is not a common side effect for everyone. Weight changes, including both weight gain and weight loss, have been reported by people taking Trazodone, but weight gain tends to be less frequent compared to other antidepressants.

How long does Trazodone last?

Trazodone's effects typically last around 6 to 9 hours. However, the duration can vary depending on the individual, dosage, and whether it's being used for sleep or depression.

How long does Trazodone take to work?

Trazodone usually takes about 30 minutes to 2 hours to start working when used for sleep. For depression, it may take several weeks (2 to 4 weeks) to feel its full effects. For some it can take even longer (around 4-6 weeks) to get its full effect.

Is Trazodone a narcotic?

No, Trazodone is not a narcotic. It is an antidepressant classified as a serotonin modulator and is not considered addictive or a controlled substance.

How long does Trazodone stay in your system?

Trazodone can stay in your system for approximately 1 to 3 days. Its half-life is around 5 to 13 hours, meaning it takes about this long for half of the drug to be eliminated from your body. Complete elimination may take longer depending on factors like metabolism, dosage, and individual health.

Is Trazodone a strong sleeping pill?

No, Trazodone is not a sleeping pill, it is an antidepressant. However, it can be used to help those struggling with insomnia as a sleeping aid, especially at lower doses, but it’s not considered a "strong" sleeping pill compared to other medications like benzodiazepines or prescription sleep aids.

Is Trazodone 50 mg a narcotic?

No, Trazodone 50 mg is not a narcotic. Trazodone is an antidepressant classified as a serotonin modulator and is not considered addictive or a controlled substance.